YCW Lab
Cancer Biology/tumor-immunology Lab
Dr. Yi-Ching Wang's laboratory has a long-standing research interest on the molecular mechanisms involved in lung tumorigenesis. Her group investigates the etiological association of alterations in tumor suppressor genes and oncogenes with lung tumorigenesis. Dr. Wang has continued to do research on cancer genomics and epigenomics of DNA methylation and chromatin alteration profiles for identification of new genes critical to lung tumorigenesis. More recently, Dr. Wang focuses on the role of Rab37 small GTPase in regulation of exocytosis and malfunction of Rab37 in tumorigenesis and tumor microenvironment. In addition, Dr. Wang's group investigates the underlying mechanisms of NRF2 antioxidant transcription factor in cancer progression and drug resistance. Several potential anti-cancer drugs and antibodies also are developing in her laboratory.
- Latest Research -
Rab37 mediates trafficking and membrane presentation of PD-1 to sustain T cell exhaustion in lung cancer
Source: J Biomed Sci. 2024 Feb 7;31(1):20
doi: 10.1186/s12929-024-01009-6.
Wan-Ting Kuo, I-Ying Kuo, Hung-Chia Hsieh, Ssu-Ting Wu, Wu-Chou Su, Yi-Ching Wang
Source: J Biomed Sci. 2022 Oct 30;29(1):90.
doi: 10.1186/s12929-022-00873-4.
Chih-Hsiung Hsieh, Wen-Hui Kuan, Wei-Lun Chang, I-Ying Kuo, Hsun Liu, Dar-Bin Shieh, Hsuan Liu, Bertrand Tan & Yi-Ching Wang
Source: J Biomed Sci. 2022 Aug 5;29(1):56.
doi: 10.1186/s12929-022-00837-8.
I.‑Ying Kuo, Chih‑Hsiung Hsieh, Wan‑Ting Kuo, Chih‑Peng Chang* and Yi‑Ching Wang*
Targeting protumor factor chitinase-3-like-1 secreted by Rab37 vesicles for cancer immunotherapy
Source: Theranostics 2022; 12(1): 340-361.
doi: 10.7150/thno.65522
Pei-Shan Yang*, Min-Hua Yu*, Ya-Chin Hou*, Chih-Peng Chang, Shao-Chieh Lin, I-Ying Kuo, Pei-Chia Su, Hung-Chi Cheng, Wu-Chou Su, Yan-Shen Shan, Yi-Ching Wang.
Source: Theranostics 2021; 11(14): 7072-7091.
doi: 10.7150/thno.57803
Chih-Hsiung Hsieh*, Hung-Chia Hsieh*, Fu-Shiuan Shih*, Pei-Wen Wang, Li-Xing Yang, Dar-Bin Shieh, Yi-Ching Wang.
Source: Theranostics 2021; 11(14): 7029-7044.
doi: 10.7150/thno.60040
I-Ying Kuo, You-En Yang, Pei-Shan Yang, Yu-Jou Tsai, Hong-Tai Tzeng, Hung-Chi Cheng, Wan-Ting Kuo, Wu-Chou Su, Chih-Peng Chang, Yi-Ching Wang.
Source: Theranostics, 10(22),p 10001-10015. (2020)
doi: 10.7150/thno.47491
Che-Chung Lin, I-Ying Kuo, Li-Ting Wu, Wen-Hui Kuan, Sheng-You Liao, Jayu Jen, You-En Yang, Cheng-Wei Tang, Yi-Rong Chen, Yi-Ching Wang.
ST2 Signaling in the Tumor Microenvironment
Source: Tumor Microenvironment pp 83-93 (2020)
doi: 10.1007/978-3-030-38315-2_7
Chih-Peng Chang, Meng-Hsuan Hu, Yu-Peng Hsiao, Yi-Ching Wang.
Source: Oncogene volume 38, p6723-6736 (2019)
doi: 10.1038/s41388-019-0928-x
Sheng-You Liao, I-Ying Kuo, Yu-Ting Chen, Pao-Chi Liao, Ya-Fen Liu, Hsin-Yi Wu, Wu-Wei Lai & Yi-Ching Wang.
Source: Journal of biomedical science. Vol. 26, No. 1. (2019)
doi: 10.1186/s12929-019-0510-4
I-Ying Kuo, Yu-Lin Huang, Chien-Yu Lin, Chien-Hsun Lin, Wei-Lun Chang, Wu-Wei Lai, Yi-Ching Wang
Source: Cell Death & Differentiation vol 26, p 1283-1298 (2018)
doi: 10.1038/s41418-018-0204-6
Jayu Jen, Chun-Yen Liu, Yu-Ting Chen, Li-Ting Wu, Yang-Chih Shieh, Wu-Wei Lai, Yi-Ching Wang
Source: Cell Death & Disease vol 9: 868 (2018)
doi: 10.1038/s41419-018-0915-0
Shu-Huei Cho, I-Ying Kuo, Pei-Jung Frank Lu, Hong-Tai Tzeng, Wu-Wei Lai, Wu-Chou Su, Yi-Ching Wang
Our work is supported by:
