Cancer Biology/tumor-immunology Lab

Dr. Yi-Ching Wang's laboratory has a long-standing research interest on the molecular mechanisms involved in lung tumorigenesis. Her group investigates the etiological association of alterations in tumor suppressor genes and oncogenes with lung tumorigenesis. Dr. Wang has continued to do research on cancer genomics and epigenomics of DNA methylation and chromatin alteration profiles for identification of new genes critical to lung tumorigenesis. More recently, Dr. Wang focuses on the role of Rab37 small GTPase in regulation of exocytosis and malfunction of Rab37 in tumorigenesis and tumor microenvironment. In addition, Dr. Wang's group identifies an oncogenic zinc finger transcription factor ZNF322A and investigates the underlying mechanisms of ZNF322A in cancer progression. Several potential anti-cancer drugs and antibodies also are developing in her laboratory.

- Latest Research -

Targeting protumor factor chitinase-3-like-1 secreted by Rab37 vesicles for cancer immunotherapy

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Source: Theranostics 2022; 12(1): 340-361. doi:10.7150/thno.65522

Pei-Shan Yang*, Min-Hua Yu*, Ya-Chin Hou*, Chih-Peng Chang, Shao-Chieh Lin, I-Ying Kuo, Pei-Chia Su, Hung-Chi Cheng, Wu-Chou Su, Yan-Shen Shan✉, Yi-Ching Wang✉

An innovative NRF2 nano-modulator induces lung cancer ferroptosis and elicits an immunostimulatory tumor microenvironment

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Source: Theranostics 2021; 11(14): 7072-7091. doi:10.7150/thno.57803

Chih-Hsiung Hsieh*, Hung-Chia Hsieh*, Fu-Shiuan Shih*, Pei-Wen Wang, Li-Xing Yang, Dar-Bin Shieh, Yi-Ching Wang

Converged Rab37/IL-6 trafficking and STAT3/PD-1 transcription axes elicit an immunosuppressive lung tumor microenvironment

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Source: Theranostics 2021; 11(14): 7029-7044. doi:10.7150/thno.60040

I-Ying Kuo, You-En Yang, Pei-Shan Yang, Yu-Jou Tsai, Hong-Tai Tzeng, Hung-Chi Cheng, Wan-Ting Kuo, Wu-Chou Su, Chih-Peng Chang, Yi-Ching Wang

Dysregulated Kras/YY1/ZNF322A/Shh transcriptional axis enhances neo-angiogenesis to promote lung cancer progression 

Source: Theranostics, 10(22),p 10001-10015. (2020) doi:10.7150/thno.47491

Che-Chung Lin, I-Ying Kuo, Li-Ting Wu, Wen-Hui Kuan, Sheng-You Liao, Jayu Jen, You-En Yang, Cheng-Wei Tang, Yi-Rong Chen, Yi-Ching Wang

ST2 Signaling in the Tumor Microenvironment

Source: Tumor Microenvironment pp 83-93 (2020)

Chih-Peng Chang, Meng-Hsuan Hu, Yu-Peng Hsiao, Yi-Ching Wang

AKT-mediated phosphorylation enhances protein stability and transcription activity of ZNF322A to promote lung cancer progression

Source: Oncogene volume 38, p6723-6736 (2019) 

Sheng-You Liao, I-Ying Kuo, Yu-Ting Chen, Pao-Chi Liao, Ya-Fen Liu, Hsin-Yi Wu, Wu-Wei Lai & Yi-Ching Wang 

SOX17 overexpression sensitizes chemoradiation response in esophageal cancer by transcriptional down-regulation of DNA repair and damage response genes.

Source:  Journal of biomedical science. Vol. 26, No. 1. (2019)

Kuo, I. Ying ; Huang, Yu Lin ; Lin, Chien Yu ; Lin, Chien Hsun ; Chang, Wei Lun ; Lai, Wu Wei ; Wang, Yi Ching.  

Oncogenic zinc finger protein ZNF322A promotes stem cell-like properties in lung cancer through transcriptional suppression of c-Myc expression

Source: Cell Death & Differentiation vol 26, p 1283-1298 (2018)

Jen, Jayu ; Liu, Chun-yen ; Chen, Yu-ting ; Wu, Li-ting ; Shieh, Yang-chih ; Lai, Wu-wei ; Wang, Yi-ching.

Rab37 mediates exocytosis of secreted frizzled-related protein 1 to inhibit Wnt signaling and thus suppress lung cancer stemness

Source: Cell Death & Disease vol 9: 868 (2018) 

Cho, Shu-huei ; Kuo, I-ying ; Lu, Pei-jung Frank ; Tzeng, Hong-tai ; Lai, Wu-wei ; Su, Wu-chou ; Wang, Yi-ching.

Our work is supported by:

YCW lab, No. 1 University Road, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan
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