Yi-Ching Wang

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ResearchGate: Yi-Ching Wang

Wiley-Publons: J-8702-2019

Scopus: Author ID: 57154892900

ORCiD: https://orcid.org/0000-0002-7694-2067

Research NCKU: https://researchoutput.ncku.edu.tw/en/persons/yi-ching-wang/

Yi-Ching Wang, PhD  王憶卿 教授

Dr. Yi-Ching Wang received her PhD in Genetics from Michigan State University, USA, in 1993. She returned to Taiwan to pursue postdoctoral training at the Institute of Biomedical Sciences, Academia Sinica. In 1995, Dr. Wang became an Associate Professor at the Institute of Toxicology, Chung Shan Medical University. She subsequently joined the Department of Life Science at National Taiwan Normal University and was promoted to Professor in 1999. In 2006, Dr. Wang moved to the Department of Pharmacology, College of Medicine, National Cheng Kung University, where she served as a Distinguished Professor until 2015, when she took up the current position as Chair Professor at the same university.

As a Principal Investigator since 1995, Dr. Yi-Ching Wang has published more than 150 SCI-indexed papers in leading journals, including Journal of Clinical Oncology, Journal of Thoracic Oncology, Journal of Clinical Investigation, Nature Communications, Science Advances, Nucleic Acids Research, Cell Death & Differentiation, Cancer Research, and Theranostics. In addition, her research group has published over 500 conference papers and four book chapters, and has been granted four Taiwan patents, two U.S. patents, and two PCT patents.

Dr. Wang has a longstanding research interest in elucidating the molecular mechanisms underlying tumorigenesis in lung, esophageal, pancreatic, and colorectal cancers. Her work specifically examines how alterations in tumor suppressor genes and oncogenes affect cancer signaling pathways. Over the years, her research has focused on cancer genomics and epigenomics, with particular emphasis on DNA methylation, chromatin remodeling, post-translational modifications, exocytosis, and the tumor microenvironment.

Dr. Wang's team investigates the role of NRF2, an antioxidant transcription factor, in cancer progression and drug resistance. In parallel, her laboratory studies the function of the small GTPase Rab37 in exocytosis, the consequences of Rab37 dysregulation in tumorigenesis, and its impact on the tumor microenvironment. More recently, Dr. Wang's research has expanded to post-translational modifications of inhibitory receptors on immune cells and their roles in immune modulation during tumorigenesis. The stromal–cancer crosstalk that shapes the tumor microenvironment and drives cancer progression is also a major focus of her laboratory. In addition, her group investigates cancer-related transcription factors, including NF-κB, STAT3, Oct4, ZNF322A, and SOX17, as well as cytokines and secretory factors such as IL-2, IL-6, IL-33, CCL2, and chitinase-3-like protein 1.

Beyond fundamental research, Dr. Wang's laboratory is actively engaged in the development of novel anticancer small-molecule therapeutics, immunomodulatory antibodies, and cytokines. These ongoing efforts aim to translate fundamental scientific discoveries into clinically applicable strategies that ultimately benefit cancer patients.

Research Interests

• Post-translational modifications of immune checkpoints
• Vesicle trafficking and tumor microenvironment
• Stromal-cancer cross-talk in the tumor microenvironment
• Transcription deregulation in cancer
• Cancer signaling
• Anticancer drug/antibody development
• Translational medicine

Education and Experience

• 1993 PhD, Genetics, Michigan State University 美國密西根大學 遺傳博士
• 1995 Associate Professor, Molecular Toxicology, Chung Shan Medical University 中山醫學大學分子毒理所 副教授
• 1999 Professor, Life Science, National Taiwan Normal University 國立台灣師範大學生命科學系 教授
• 2006 Distinguished Professor, Pharmacology & Basic Medical Sciences, National Cheng Kung University 國立成功大學藥理所/基醫所 特聘教授
• 2015 Chair Professor, Pharmacology & Basic Medical Sciences, National Cheng Kung University 國立成功大學藥理所/基醫所 講座教授
• 2015-2018 President, The Taiwan Society For Biochemistry And Molecular Biology 台灣生化學會 理事長
• 2026-2028 Convener, The Division of "Research in Pharmacy and Chinese Medicine", National Science and Technology Council 國科會生科處 藥學及中醫藥學學門 召集人

Honors / Awards 

2024

• The National Science and Technological Council Designated Research Fellow Award 國科會傑出特約研究員獎

2023

• The 19th Tien Te Lee Biomedical Awards 第19屆永信李天德醫藥科技獎--卓越醫藥科技獎

2022 

• 66th Academic Award of Ministry of Education 第66屆教育部學術獎 

2021-2023

• The Foundation for the Advancement of Outstanding Scholarship Award 傑出人才基金會傑出人才講座

2018

• K.T. Li Honorary Scholar Award, Taiwan 李國鼎科技與人文講座榮譽學者獎

2017

• Dr. Wang Min-Ning Memory Foundation for Excellent Basic Medical Research award, Taiwan 財團法人王民寧先生紀念基金會【基礎醫學類】傑出貢獻獎

2017~2023

• Merit MOST Research Fellow Award, Taiwan科技部特約研究

2013

• Dr. Tung Ta-Cheng Memorial Award for Basic Cancer Research, Chinese Oncology Society, Taiwan 董大成博士癌症基礎醫學研究傑出獎

2008

• Outstanding research award, Pharmacology Society, Taiwan藥理學會傑出研究獎

2007

• Distinguished alumnus of Chinese Culture University, Taiwan 文化大學傑出校友

2004, 2010, 2014

• NSC/MOST Excellent Research Award, Taiwan 國科會/科技部傑出研究獎

 Publications